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KMID : 0364020070400040273
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Korean Journal of Thoracic and Cardiovascular Surgery
2007 Volume.40 No. 4 p.273 ~ p.279
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Blood Protein Adsorption and Platelet Activation on an Ultra-hydrophilic Substrate
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Park Nam-Hee
Lee Jae-Won
Chun Bae-Hyeock
Je Hyung-Gon
Lee Jun-Wan
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Abstract
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Background: We evaluate the efficacy of ultra-hydrophilic coated bypass circuits in comparison with uncoated bypass circuits in a porcine cardiopulmonary bypass model.
Materials & Methods: Normothermic cardiopulmonary bypass was performed in 10 anesthetized pigs via the left atrium and ascending aorta with a centrifugal biopump. Ultra-hydrophilic coated bypass circuits were used in 5 pigs (the study group) and uncoated bypass circuits were used for the control group. Platelet counts and platelet aggregation tests were performed. The thrombin-antithrombin (TAT) complex level and total protein level were evaluated.
Results: There were no significant changes in the platelet counts and aggregation ability of both groups. The TAT complex levels were not different between the two groups. The total protein level was significantly lower in the control group after cessation of cardiopulmonary bypass.
Conclusion: The clinical effects of ultra-hydrophilic coating circuits were not remarkable, in terms of reducing inflammatory reaction and protection of platelet function. However, the effect of protection for blood protein adsorption might be acceptable.
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KEYWORD
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Cardiopulmonary bypass, inflammatory response
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